Lyophilized Sema Powder
Overview
Sema. is a synthetic analog of the human glucagon-like peptide-1 (GLP-1), engineered to enhance stability and prolong activity.
Key Features
-
Mechanism of Action: Binds to and activates GLP-1 receptors, promoting glucose-dependent insulin secretion, delaying gastric emptying, and reducing appetite.
-
Metabolic Effects: Studies indicate potential benefits in glycemic control and weight reduction in preclinical models.
-
Pharmacokinetics: Modified structure confers resistance to enzymatic degradation, resulting in a prolonged half-life suitable for weekly administration in research protocols.
-
Research Applications: Employed in investigations related to type 2 diabetes, obesity, and metabolic disorders.
Applications
-
Obesity & Weight‑Loss Research: Model sustained weight reduction and investigate mechanisms of appetite control in preclinical and clinical studies.
-
Diabetes & Metabolic Studies: Probe GLP‑1–mediated insulinotropic effects and glucose homeostasis in cellular assays and animal models.
-
Pharmacokinetics & Formulation: Develop and validate delivery systems, dosing regimens, and PK/PD models for weekly peptide therapeutics.
-
Cardiometabolic Research: Explore secondary benefits on blood pressure, lipid profiles, and cardiovascular risk markers.
Specifications
| Attribute | Specification |
|---|---|
| Form | White to off‑white lyophilized powder |
| Purity | ≥ 99 % by HPLC |
| Molecular Weight | ~4115 Da |
| Half‑Life | ~7 days |
| Solubility | Soluble in DMSO; ≥ 0.2 mg/mL in 1:4 DMSO:PBS (pH 7.2) |
| CAS Number | 910463‑68‑2 |
| Storage | −20 °C, dry, protected from light (stable ≥ 2 years) |
MARK G. (verified owner) –
The packaging is very impressive and they have the fastest shipping I’ve ever experienced. Very happy with the process, communication and the product.
Danielle (verified owner) –
Easy website and fast shipping! Cute packaging as well!
Danielle (verified owner) –
Very fast shipping.
Amanda and Joshua (verified owner) –
High quality products and great customer support!!
Kelsi Gardner (verified owner) –
This is my 3rd purchase. Never had an issue
Samantha (verified owner) –
Cherize Johnson (verified owner) –
Anonymous (verified owner) –
Danielle (verified owner) –
Steffany K. (verified owner) –
Repeat customer here! Excellent product, high quality!! Packaged nicely and shipping was fast as well. Highly recommend.
Jennifer (verified owner) –
Yesenia (verified owner) –
This is my second order from Advanced Research and both times I’ve received quality products and really fast shipping. Customer support is top-notch. Highly recommend!
Priscilla H. (verified owner) –
As usual, best customer service and quick and easy and very fast delivery!
Priscilla H. (verified owner) –
Number one trusted company I’ve used with great customer service wouldn’t go elsewhere.!
Cherize Johnson (verified owner) –
Brian (verified owner) –
💯 customer service is night and day compared to their competitors. Shipping is lightning fast. Payment method takes some getting use to, but I get it. Product is legit and the packaging seems like it was done with love and makes it all seem personal. I’m not going anywhere else.
Nadine C. (verified owner) –
Shipping was quick and I love the packaging it came in. Any questions were answered quickly. Overall great experience and would buy from here again.
Jennifer Morris (verified owner) –
Anonymous (verified owner) –
Rose Hobgood (verified owner) –
Perfect for my needs.
Anonymous (verified owner) –
kaila d. (verified owner) –
Joshua (verified owner) –
Christie Hurst (verified owner) –
Yesenia (verified owner) –
Great product and fast shipping as usual!
Michelle (verified owner) –
Jennifer Morris (verified owner) –
Lisa M. (verified owner) –
Joleen (verified owner) –
Richard Crain (verified owner) –
Awesome products quick delivery.
Crystal (verified owner) –
Excellent customer service
Debra Woodall (verified owner) –
Wonderful!
Lauren (verified owner) –
Best Customwr Service Also
Stacy W. (verified owner) –
Excellent quality, service and value!
Janice P. (verified owner) –
Everything went smooth and is working great.
Anonymous (verified owner) –
Great came fast
Rebecca (verified owner) –
Anonymous (verified owner) –
Anonymous (verified owner) –
Alanna (verified owner) –
Seller is incredibly responsive and reassuring. This was such an amazing experience. They shipped quickly, and the only delay occurred because of weather, which is totally not on the business. Owner was so concerned about satisfaction they followed up and made sure I received item and was satisfied. Really such an amazing company and experience and I’m so glad to have found them. ❤️❤️❤️
Veronica Wilson (verified owner) –